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Despite the high lipophilicity of these agents (the log octanol/physiological saline partition coefficient equalled 2.14 and 1.68, respectively), the cerebrovascular permeability-surface area product, PA, of vincristine in plasma was only 0.49 x 10(-4) ml s-1 g-1 for parietal cerebral cortex, whereas that of vinblastine was too low for determination. We report on a patient with the biological hallmarks of AT but with atypical clinical manifestations.

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The goal of this study is to examine the effectiveness of a trial of cognitive remediation for forensic mental health patients with schizophrenia or schizoaffective disorder. Thirty individuals with acquired brain injury and 18 sedentary controls (SC) participated.

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The calculated quantum correlation functions for the two methods are shown to be in good agreement with one another for a large portion of the time spectrum. injection of 1 or 2 micrograms DES/g body weight during late pregnancy.

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The differences in drug response between in vivo and in vitro growth have important implications for predicting chemotherapeutic response using tumor biopsies from patients or patient-derived xenografts. The role of corticosterone in the development of pancreatic enzymes of suckling rats was studied through a partial and transient blockade of steroidogenesis by aminoglutethimide.

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This study used a randomized design to assess the impact of a presurvey letter on response rates to a telephone survey, as well as prevalence estimates of ever having used an indoor tanning facility. Chemosensitivity testing of irinotecan (CPT-11) in ovarian and endometrial carcinomas: a comparison with cisplatin.

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The aim of this study was to investigate the illness perceptions of people with dysphonia. Nasopharyngeal temperature of 43 degrees C was attained after 15-20 minutes of anaesthesia.

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Preoperative diagnostics, if conducted at all, only rarely lead to the diagnosis of cecal diverticulitis. In this paper an attempt is made to draw up an environmental model for sows. Human papillomaviruses (HPVs) are a diverse family of viruses, of which 30-40 genotypes specifically infect the genital tract.

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This is the case when the auras are frequent, prolonged and cause anxiety and distress. Epidermal growth factor (EGF) was observed to stimulate the tubule formation and the contraction of the lattices. MSG-treated mice became obese in the absence of increased food intake and their core temperature was significantly lower compared to control mice. The effect of lidocaine and procainamide on the electrocardiogram of a patient with coupled ventricular premature depolarizations was observed after continuous electrocardiographic monitoring during a control period and drug therapy.

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This review examines the current knowledge about natural compounds and their mechanisms that underlie breast cancer chemopreventive activity both in vitro and in vivo. Smoking clustered with harmful alcohol use, as well as physical inactivity.

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Preventing medical noncompliance in the outpatient treatment of bipolar affective disorders. For vertebrate development, vitamin A (all-trans retinol) is required in quantitative different amounts and spatiotemporal distribution for the production of retinoic acid, a nuclear hormone receptor ligand, and 11-cis retinal, the chromophore of visual pigments. The exact molecular function(s) of GAP-43 remains unclear but it appears to be involved in growth cone guidance and actin cytoskeleton organization.

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They also demonstrated a greater than normal reabsorptive rate of glucose per unit measured glomerular filtration rate. The role of academic health systems in promoting population health. Further well-designed studies may help clarify the role mechanical techniques will play in future combinations of interventional therapy. Temporal fluctuations in oribatid mites indicate that density-independent factors favour parthenogenetic reproduction. Yeast two-hybrid, GST-pulldown, and coimmunoprecipitation assays showed that Ubc9 interacted with N-terminal MR-(1-670).

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A novel pseudo resistor structure for biomedical front-end amplifiers. Structure of hiptagin as 1,2,4,6-Tetra-O-(3-nitropropanoyl)-beta-D-glucopyranoside, its identity with endecaphyllin X, and the synthesis of its methyl ether. Based on this and previously published information we propose a spatial model for the spike structure at the vertices. We conclude that in invasive cervical carcinomas widespread overexpression of p53 protein is unusual, but occasional positive nuclei can be found frequently. SPLN binds more strongly to dioleoylphosphatidylglycerol vesicles compared to dioleoylphosphatidylcholine and phosphatidylserine vesicles.

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High-performance liquid chromatographic determination of cardenolides in Digitalis leaves after solid-phase extraction. Tissue blot analysis showed that the proteinase inhibitor I proteins were located throughout the fruit tissue, with the exception of the seeds. Selective cortical NA depletion produced deficits on the 5CSRT test of sustained attention, especially when the attentional load was increased and in response to systemic guanfacine. Nonsegmental inhibition of rat dorsal horn neurons by innocuous stimulation.

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Growth-related expression of a double-stranded RNA-dependent protein kinase in 3T3 cells. A hydrogen-bonding network modulating enzyme function: asparagine-194 and tyrosine-225 of Escherichia coli aspartate aminotransferase. One of the responses of the human macrophage to lipopolysaccharide (LPS) is the production of a number of cytokines. Effect of oral dose size on hydralazine kinetics and vasodepressor response. Morphological study of the mitochondria of the hepatic parenchyma in experimental traumatic shock

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The protonemal stage of gametophyte development comprises cell filaments that extend by the serial division of their apical cells, allowing the investigation of the generation and modification of cell polarity and the role of the cytoskeleton in these processes. Previous works have considered this type of process in the context of haploid genomes. New classes of NSAIDs that may have a more favorable safety profile than older agents may improve patient outcome.

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The larvicidal effects of polyphenols from dietary alder leaf litter were investigated in different field collections of three detritivorous Aedes taxa (Ae. The technique still requires optimization before it might be used in real casework. Careful inspection and palpation usually permit one to detect bony lesions which XRays then demonstrate only by careful choice of appropriate views.

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Biosynthesis of Arabinogalactan-Protein in Lolium multiflorum (Ryegrass) Endosperm Cells : III. The purpose of this study was to evaluate the relationship between early dental experiences and clinical indicators of oral health and dental anxiety upon admission to a comprehensive oral health program for six-year-old children in Chile. During 11 to 54 months (mean, 35.6 months) of follow-up, no further seizures occurred and none had neurological abnormalities.

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Host cell infiltration of the intraepithelial compartment in small bowel transplantation. They review current research with reference to studies conducted with individuals with intellectual disabilities or dementia, or those who have experienced stroke or traumatic brain injury, and identify deficits within existing research. Adhesion of human lung mast cells to bronchial epithelium: evidence for a novel carbohydrate-mediated mechanism.

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Attempts to block the formation of 6-acetylmorphine were not successful, although the problem is minimised by using the lowest temperature consistent with satisfactory chromatography. Their vital status and cancer morbidity were studied in the Swedish Cancer Registry, Cause of Death Registry, and Census Registry. Southern blotting analysis showed that 8 out of 11 patients had either gene deletions or inversions of the FVIII gene, indicating a higher proportion of gross gene alterations in inhibitor-positive hemophilia A patients.

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However, the initial hypoglycemic response (first 10 min) obtained from intratracheal administration of 25 IU/kg hexameric insulin appears to be slower than that from the 25 IU/kg dimeric insulin, thereby suggesting that hexameric insulin may have a lower permeability coefficient across alveolar epithelium than the dimeric insulin. Human neonatal and adult vascular smooth muscle cells in culture.

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Needs assessment and a model agenda for training the public health workforce. An apparatus suitable for the continuous measurement of oxygen consumption of rats and mice is described. In the isthmic region, the intensity of staining surpassed that of the tectum and reached its maximum at E17 and then slowly decreased till the end of the experimental period (120 days post-hatched).

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This study was undertaken to analyse the diffusion characteristics of synovial fluid in degenerative and inflammatory arthropathies. Erk signaling plays a critical role in maintaining the pluripotency of mouse embryonic stem cells (ESCs).

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A simple set of questions inquiring about dizziness, headache, and cognitive issues may provide diagnostic accuracy. Scanning electron microscopy revealed severe loss in structural integrity of plasma-treated cells, and optical emission spectra indicated that inactivation was brought about by reactive plasma species. Aberrant activation of mTORC1 in cardiomyocytes was associated with myocardial fibrosis and a trend for worse prognosis in patients with NICM, indicating that persistently activated mTORC1 contributes to progression of human heart failure.

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Age differences in understanding of disease causality: AIDS, colds, and cancer. Male patients had a significantly higher number of metabolic abnormalities than female patients, especially in group 1. The fine structure of the methaphase chromosomes from the Chinese hamster cell culture was studied after the incubation with lyposomes isolated from hen egg yolk phosphatidilcholine, or from the total rat liver phospholipid. These results demonstrate an important role of beta 1 integrins in hair follicle morphogenesis, in the processing of basement membrane components, in the maintenance of some, but not all basement membranes, in keratinocyte differentiation and proliferation, and in the formation and/or maintenance of hemidesmosomes. We consider the properties of a one-dimensional fluid of Brownian inertial hard-core particles, whose microscopic dynamics is partially damped by a heat bath.

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Cerebral perfusion pressure, cerebral blood flow, and pial artery diameter were determined before and after fluid percussion injury in piglets equipped with a closed cranial window and post-treated with norepinephrine. In Central Europe (Switzerland, Basel) and in the cancer registries of Iceland (Northern Europe), France, Bas-Rhin and Calvados, Southern Ireland, and the Netherlands, Eindhoven (Western Europe) no rise in incidence was observed. This study assessed different factors, namely socio-demographic, cancer-related, psychological, social cognitive factors (attitude, social support, self-efficacy) and intention, in relationship to five lifestyle behaviors (smoking, physical activity, alcohol, and fruit and vegetable consumption). Preservation of ovarian function after lateral ovarian transposition. A software program was written to record information on a central database each time the CCG were used.

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A comparative study of the inhibiting effects of anionic polyelectrolytes on deoxyribonucleases. Influence of neonatal age on changes in fatty acid composition of microsomal lipids induced by long-term and short-term cholesterol feeding. There was no evidence of a rise in the standardised prevalence rate between 1902-9 and 1953-73.

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Patients from the three groups differed in illness onset, diagnosis, number of episodes and admissions, family history, comorbidities, rapid cycling and medication, as well as level of education, functioning, impulsivity and temperamental profile. Intensive care unit and hospital lengths of stay, time to correction of anion gap and ketone clearance, and hypoglycemic episodes. Two patients with common variable immunodeficiency (CVID) and malignant tumours are reported.

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Employers are playing an increasingly influential role in determining the scope and character of health coverage in the United States. A case of hemangioma involving the orbit and jaw associated with thrombocytopenia in a 1-month-old boy was reported. Recommendations for further experimental study addressing design limitations of this pilot study are discussed.

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Pleurodesis using an acrylate glue in the treatment of therapy-resistant symptomatic pneumothorax Soluble sugars have been shown to protect liposomes and lobster microsomes from desiccation damage, and a protective role has been proposed for them in several anhydrous systems. Over 50 bile acids were identified in the amniotic fluids, these included C-1, C-4, and C-6 hydroxylated species and reflected primary hepatic synthesis by the fetus. The prevalence of other fractures and conditions in these patients was investigated.

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Effect of neurotropin on SART stress (stress caused by alteration of rhythms in environmental temperature) in mice and rats To evaluate the consequences of GPIb-V-IX deficiency in thrombosis we generated mouse models of the disease by targeting the GPIb beta subunit. Cavinton (apovincaminic acid) and fosfomycin represent examples of experimental agents being evaluated in laboratory animals for application as potential treatments to limit the ototoxicity associated with various drugs. Group A patients were examined with a conventional radiological unit and an industrial film and a conventional radiological unit with a mammographic film with a dedicated screen, while group B patients with a mammographic with an industrial film and a conventional radiologic unit with a mammographic film with a dedicated screen.

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Lessons learned--resolving the enigma of genetic factors in IBS. RATIONALE AND KEY POINTS: This article aims to help nurses to perform first aid in a safe, effective and patient-centred manner.

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LGs were prepared for hematoxylin and eosin staining or immunostaining of AQP5. The status of the institutions responsible for the quality of care in hospitals and the significance of quality indicators are explained. The purpose of this review is to summarize the current knowledge about in vivo confocal microscopy of the ocular surface. Conditions Favorable for the Somatic Embryogenesis in Carrot Cell Culture Enhance Expression of the roIC Promoter-GUS Fusion Gene.

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The enzymatic conversion of pyridine-hemichromogen into 656 mu substance by cell sap of guinea-pig liver. Spontaneous activation of heat shock protein gene transcription in peripheral blood mononuclear cells of individuals with active systemic lupus erythematosus.

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Corticosteroid responses to the psycho- therapy of reactive depressions. Chronic fluoxetine increases cytosolic phospholipase A(2) activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat.

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A previous report demonstrated that 2AAF-induced liver hyperplastic nodules displayed a persistent loss of cytosolic N-OH-2AAF sulfotransferase activity following a hepatocarcinogenesis-producing regimen of 2AAF administration. Native 80,000 and 66,000 MW alpha 4 chains on activated T cells could not be digested further by trypsin.

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In Aspergillus oryzae and in five strains of Aspergillus niger, pyruvate carboxylase activity was detected both in the mitochondrial fraction and in the cytosol. Microsomal protein synthesis and induction of cytochrome P-450 in cirrhotic rat liver. Rebound thymic hyperplasia following high dose chemotherapy and allogeneic BMT.

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Poly(ether ester) segmented copolymers were engineered as model material systems to elucidate the interfacial molecular events that govern the function of adhered cells. Development at Cold-Hardening Temperatures : The Structure and Composition of Purified Rye Light Harvesting Complex II. Decisive presurgical role of MIBI SPECT/CT in identifying within a calcific thyroid nodule the parathyroid responsible for primary hyperparathyroidism. Cyanobacterin also inhibited the growth of angiosperms, including the aquatic, Lemna, and terrestrial species such as corn and peas.

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Photosynthetic energy conversion was investigated in five species of marine unicellular algae, (Dunaliella tertiolecta, Thalassiosira pseudonana, T. The expression vector including DT(389)-hbFGF fused gene was constructed and expressed successfully. This response is triggered by the fastest afferents in the pudic nerve. The results suggest that the overall stimulus shape rather than processing mode or specific spatial frequency is a primary determinant of hemispheric differences for visual information. However, the mapping between the optical variables (tau and .tau) and the kinematic variables (velocity, acceleration) has been misstated, erroneously implying that there exist critical values of the optical variables used for locomotion and control.

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Overexpression of protease-deficient DegP(S210A) rescues the lethal phenotype of Escherichia coli OmpF assembly mutants in a degP background. Presepsin (sCD14-ST) secretion and kinetics by peripheral blood mononuclear cells and monocytic THP-1 cell line. The single-chamber version of Rhythm ID demonstrated high specificity without compromising sensitivity. Negligible interference by spironolactone and prednisone in digoxin radioimmunoassay.

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The acid protease was completely unaffected by chelators, but data on the neutral protease were equivocal.All protein substrates tested were attacked by both enzymes, though at strikingly different rates. The high adsorption capacity depends on their morphology, which is changed largely by sericin concentration in their fabrication. Fine-mapping has narrowed QVE7 (a gamma-tocopherol quantitative trait loci) to an 8.5-kb interval encompassing two genes. Similarity of A(3)-adenosine and swelling-activated Cl(-) channels in nonpigmented ciliary epithelial cells.