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Candistat (Itraconazole)

Candistat is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It′s different formulations are used to study Candida strains in murine invasive infections. Candistat inhibits cytochrome P-450-dependent enzymes which results in the inhibition of ergosterol synthesis. It does so by interacting with 14-α demethylase, which is a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Ergosterol is a crucial compenent of fungal cell membranes. Therefore, it′s inhibition results in increased cellular permeability causing leakage of cellular contents. Candistat may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Other names for this medication:
Itraconazole, Sporanox, Fulcover, Icoz, Candistat,

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Candistat is an azole antifungal medication used to treat a variety of fungal infections. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This drug may also be used to prevent certain fungal infections in patients with HIV.

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Chloroplast Biogenesis 34: SPECTROFLUOROMETRIC CHARACTERIZATION IN SITU OF THE PROTOCHLOROPHYLL SPECIES IN ETIOLATED TISSUES OF HIGHER PLANTS. The pattern of aberrations is in general non-symmetric, suggesting that the development of aberrations follow independent paths in many right and left eye pairs. The primary aim of this work was to compare the efficacy of valdecoxib 10, 20, and 40 mg QD with that of placebo and naproxen 500 mg BID in patients with rheumatoid arthritis (RA). Ultrastructural development of first- to second-generation merozoites in Eimeria contorta Haberkorn, 1971.

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The position of the gradient is calculated for our experimental configuration and we have simulated the effects of selective pulses to determine the excited volume. The findings indicate that the diets of these girls tended to be inadequate both for macronutrients and micronutrients, with significant health implications. This was objective of the international information technology (IT) Hansa-East Project dedicated to promotion of UE standards CEN/TC251 ENV 12967-1 for open architecture of hospital information systems.

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This is particularly problematic when operating close to sensitive structures such as nerves. In spleen MAP3 is found in cells of the white pulp surrounding central blood vessels. Lignin biosynthesis at the site of attempted fungal penetration may play an important role in the resistant response of reed canarygrass to leaf-infecting fungi.

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We scanned 18 normal volunteers with a 2D spiral scan and measured global thresholds for axial, sagittal, and coronal planes. Insecticidal toxin from Bacillus thuringiensis is released from roots of transgenic Bt corn in vitro and in situ. The cognitive behavioral anger management program improves private self-consciousness in soldiers. Pulse oximetry was used to monitor hemoglobin saturation (SpO2) during oral feeding of five children with multiple disabilities who were referred because of food refusal or coughing and fatigue during feeding. Intradiaphragmatic bronchopulmonary sequestration: a case report and review

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We observed that the augmentation of Hsp70 expression inhibited Ang II-stimulated VSMC hypertrophy. We have recently reported that salicylic acid and benzoic acid are oxidized by stimulated granulocytes Polymorphonuclear Neutrophils (PMN). Hemorrhage in the infant from vitamin K deficiency should be a concern for pediatricians and obstetricians.

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40 children, aged between 12 months and 15 years with no clinical history of varicella, were vaccinated with live varicella vaccine. The increasing age of the population and the longer survival of the oldest people results in more unstable and more comminuted fractures, which have increased by a factor of nearly 3 during the past three decades.

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Among the proteins hyper-accumulated in gid1 were osmotin, triosephosphate isomerase, probenazole inducible protein (PBZ1) and pathogenesis-related protein 10. Although nitric oxide is overproduced by macrophages and neutrophils after exposure to silica, its role in silica-induced inflammatory reaction and apoptosis needs further clarification.

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We used data from a large, population-based case-control study of oral cancer risk factors conducted in four areas of the United States. Broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of the extracts, as well as those of antibiotics in association with the extracts. We herein describe CD9 (p24) antigen as existing on the cell surface of megakaryocyte lineage leukemias as well as megakaryocytic leukemia cell line, MEG-01 and HEL, by means of fluorescence-activated cell sorter (FACS IV) with a panel of monoclonal antibodies (Mabs). The sad fact is that no real advance in the treatment of the disease has been made. I show that discontinuous gas exchange is unlikely to be a mechanism for reducing water loss in these insects and that the lipid properties are primarily responsible for variation in overall water loss rates.

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23 of 27 benign thyroid nodular goiters were negative for Gal-3 expression. These cases support the autosomal recessive transmission and the expansion of the phenotype of the Hennekam syndrome.

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Isolation and Characterization of a Ferredoxin Gene from Arabidopsis thaliana. Observations on the measurement and evaluation of endotoxemia by a quantitative limulus lysate microassay.

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A comparison of pretreatment regimens for minimizing the haemodynamic response to blind nasotracheal intubation. There is consistent correlation between OHRQoL and somatization. Another case of probable Kawasaki Disease occurring in Anchorage, Alaska Native Medical Center, in 1965, is presented and compared with the other four. The effect identical to that achieved as a result of 5-day storage of the solvent system under usual conditions can be reached with the first scheme during 6 hours and with the second scheme during 20-30 min.

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We studied the usefulness of a short screening instrument for cognitive dysfunctions (short mini mental state test) in a consecutive sample of 222 psychiatric consultation liaison patients older than 60 years of age. Demographics, MMSE score, and type and severity of dementia were recorded. A pro- or anti-inflammatory status is a potential risk factor for an adverse outcome, and elevated CRP concentrations have shown to correlate with organ failure. The experiments presented in this paper show that these free alpha-chains are capable of combining with beta-chains to form HbA and are, therefore, structurally normal.

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One of the latter cohesin domains was expressed, and the expressed protein interacted selectively with cellulosomal enzymes, one of which was identified as a family 48 glycosyl hydrolase on the basis of partial sequence alignment. Pancreatic exocrine insufficiency is usually present in patients with pancreatic diseases. A number of zoonoses also cause severe disease and loss of production in food producing animals. A T2-weighted turbo spin-echo sequence was compared with CT in immunocompromised patients with opportunistic pneumonia.

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Polymorphic simple-sequence repeat analyses at 15 loci on chromosome 1 and at 16 loci on other chromosomes confirmed parentage and revealed that a de novo mutation prior to maternal meiosis I, followed by nondisjunction in maternal meiosis II, resulted in an oocyte with two copies of the de novo mutant allele. Trials identified by searching CENTRAL, The Cochrane Collaboration database of controlled trials (2005), and the reference lists of identified trials and other systematic reviews. S-nitroso-l-cysteine releases norepinephrine in rat spinal synaptosomes. Understanding the pathophysiology behind these conditions is an essential step toward better treatment and future prevention allowing patients to enjoy nail adornments while maintaining healthy nails. Pi and AMP in plants grown with various Pi concentrations were determined, and concentrations estimated for chloroplasts, the organelle containing threonine synthase and cystathionine gamma-synthase.

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Cardiorespiratory system function in those working with tetramethylthiuram disulfide This study compares the size and morphology of the CS among patients with typical AVNRT, atypical AVNRT and accessory pathways mediated reentrant tachycardia (AVRT).

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However, the main contribution is the proposal of an artifact removal algorithm based on statistical methods, which allows to achieve even better performance but with much lower computational complexity. Does psychomotor sensitivity to alcohol predict subsequent alcohol use?

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Full three-dimensional photonic bandgap crystals at near-infrared wavelengths A feline immunodeficiency virus (FIV) provirus with a vif gene deletion (FIVDelta vifATGgamma) that coexpresses feline gamma interferon (IFN-gamma) was tested as a proviral DNA vaccine to extend previous studies showing efficacy with an FIV-pPPRDelta vif DNA vaccine. Furthermore, the renal impairment of this model progressed to chronic kidney disease with interstitial fibrosis after long-term DDC feeding. Associated with retrodisplacement of iris root and deepening of the anterior chamber angle secondary to contusion. Interplay of CodY and ScoC in the Regulation of Major Extracellular Protease Genes of Bacillus subtilis.

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A randomized trial of Zudan in the prophylaxis of nausea and vomiting induced by cisplatin Nucleotide sequence analyses of the MRP1 gene in four populations suggest negative selection on its coding region. Calcium-triggered exit of F-actin and IP(3) 3-kinase A from dendritic spines is rapid and reversible. The most important group of nonspecific drugs is that of the general anesthetics. Although there are relatively characteristic imaging findings, biopsy remains the definitive diagnostic test.

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Photosynthetic oxygen evolution was maximal over a range of salinities around 2.5 molar and the photosynthesis to respiration ratio showed a maximum at 1.5 molar NaCl. Rotational reorganization of doped cholesteric liquid crystalline films. Normal pneumographic radio-anatomy and changes in prebulbar extracerebral expansive processes Hydroxyapatite (HA) has been applied to joint prostheses as a bioactive coating to prolong their durability.

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Reaction times were slowed, and error rates increased when irrelevant stimulus features were incongruent with the required response. This is the first step towards the long-term goal of constructing a genetic risk model for OC that allows for genetic testing and quantification of risk in individuals. We examined the relationships among physical complaints, health-related quality of life (HRQL), anxiety and depression in differentiated thyroid cancer (DTC) patients under short-term hypothyroidism. The length and volume of the isolated smooth muscle cells depended on the calcium concentration used in the isolation buffer solution.

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Multivariate prognostic analysis of carcinoma of the gastric cardia and comparative study of different resections INHIBITION BY GLYPHOSATE OF PHENYLPROPANOID SYNTHESIS IN BUCKWHEAT (FAGOPYRUM ESCULENTUM MOENCH) . The occurrence of these changes after preexcitation resolution may depend on the degree of previous preexcitation. This dilator property of venous blood from the traumatized region was, however, only apparent following wounding by missiles of high velocity.

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The unique demographic details of Nepal require a paradigm shift in oral health workforce management in Nepal. The usual dose was 50-75 mg/day, with reduction according to efficacy and side effects.

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Histologic evaluation can be difficult due to the widespread atypical melanocytes that are present in the background of long-standing sun damage. We are therefore in need of new methods for mining this mountain of data in order to enable new hypothesis generation. Phylogenetic analysis of the Wnt gene family and discovery of an arthropod wnt-10 orthologue. Asymmetrical letters have more intrinsic left-to-right directionality than symmetrical elements.

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Although there are many devices available to facilitate computer entry, we believe that the digitiser technique is an attractive option because of its ease of use, speed, reliability, and low cost. War captivity includes a unique constellation of simultaneous somatic and interpersonal assaults. Here we provide a dynamical systems analysis of a canonical model for gradient frequency neural networks driven by a periodic signal. Physiological Site of Ethylene Effects on Carbon Dioxide Assimilation in Glycine max L. The heterogeneity of porcine 32,000 Mr inhibin alpha-subunit: a gel electrophoresis and immunoblot study.

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Lys49 snake-venom phospholipase A2 (PLA2) homologues are highly myotoxic proteins which, although lacking catalytic activity, possess the ability to disrupt biological membranes, inducing significant muscle-tissue loss and permanent disability in severely envenomed patients. Bleeding was monitored during surgery and for 2 weeks postoperatively. On the analysis of single versus multiple channels of electromagnetic brain signals. The results show that neither changes in membrane lipid fluidity nor transition temperature are a necessary feature of cold acclimation in wheat.

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To compare the ability of different evoked potential scores (EPS) to monitor and predict the disease course in multiple sclerosis (MS). On the basis of sensitivity testing using the disc diffusion technique and the minimum inhibitory concentration procedure and incorporation of radioactive phosphorus into nucleic acids, it was determined that A. We think that this diet and amino acid regimen is a feasible way to keep chronic severe uremic patients in fairly good general condition and nutritive state until they can have a renal transplantation or a place in a home-dialysis program.

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The histological data for the series shows that a pleural response to the action of matter excreted by the pancreas was responsible. Three hundred and fifty-seven (91.2 per cent) of the patients had ten millimeters of final shortening or less, and 306 (78.3 per cent) had a final angulation of 5 degrees or less. In this study, we incubated human umbilical vein endothelial cells (HUVECs) with IgG isolated from patients with APS and found that the HUVECs were activated by the expression of negatively charged phospholipids, as shown by high annexin V binding and negative propidium iodide staining and by an increase in the level of intracellular cell adhesion molecule-1 on the cell surface.

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Implications for the intrinsic pathway of fibrinolysis and for therapeutic thrombolysis. Assessment of the carcinogenicity of non-nutritive sweeteners I: Saccharin. Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen. We conducted tests with coumarin and 2,4,6-trinitrotoluene (two solutes that were used in initial development of PLOT-cryo technology), naphthalene, aviation turbine kerosene, and diesel fuel, on a variety of matrices and test beds.

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Thermodynamic quantities for the dissociation of three ferrihaemoproteins from soya-bean nodules. Symptomatic plaques show overexpression of CD163 and HO-1 both in intraindividual and interindividual comparison. This paper presents data regarding endothelial cell loss in aphakic and pseudophakic silicone oil filled eyes when oil was retained for many months.

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Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line. About one of every 5 athletes who participated in the 1996 Summer Olympic Games in Atlanta had a past history of asthma, had symptoms that suggested asthma, or took asthma medications. This fixation could not be attributed to contamination with 7S antibody. Physiological Studies of a Synthetic Gibberellin-Like Bioregulator: II.

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To evaluate the in vitro activity of doripenem in Acinetobacter baumannii (A. Using a novel assay for cloacal function, we find that larvae with reduced mid-gastrula Bmp signaling cannot brand new aloc acoc tabs for stairway properly excrete waste.

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