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Endoxan (Cyclophosphamide)

Endoxan is a cytotoxic (cytostatic), cell-cycle-nonspecific, antiproliferative agent that is used in such diverse medical problems as neoplasia, tissue transplantation, and inflammatory diseases. It is an inert prodrug for a potent nitrogen mustard alkylating agent. After the metabolic activation of Endoxan to the potent mustard by liver enzymes, a nonenzymatic generation of chemically reactive molecules occurs. These reactive molecules can form covalent bonds with biologically ubiquitous groups, such as amino, phosphate, hydroxyl, carboxyl, sulfhydryl and imidazole, and as a result, depending on dose, Endoxan is capable of either interfering with the reproduction of cells or killing cells. This is especially true in the case of rapidly dividing cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Amoxicilina, Lansol, Gabator, Voltex, Ismo, Amosine, Bicalox, Fibrosan, Divarius, Digoxine, Tensen, Clindal, Bestalin, Norfloxacin, Novotrim, Aldactone, Calutide, Efectin, Valax, Suprim, Flucon, Dalsan, Trandate, Inhibitron, Fabamox, Medovir, Dipazide, Oroken, Frusenex, Niravam, Torgyn, Pango, Rulide, Gabexal, Vasilip, Acycloguanosine, Clopes, Ulcesep, Dutoprol, Bioclavid,

Endoxan is used to treat various types of cancer. It is a chemotherapy drug that works by slowing or stopping cell growth. Endoxan also works by decreasing your immune system's response to various diseases. It is used to treat a certain type of kidney disease in children after other treatments have not worked. OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. This medication may also be used for various conditions such as lupus and rheumatoid arthritis, and to prevent organ transplant rejection.

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However, in the other three volunteers there was no concordance between the investigated indicators of the influence of amoxycillin on colonization resistance. The recognition of possible determinants of vaccine-associated paralytic poliomyelitis (VAPP) by public health surveillance and immunization programmes is relevant to inform the debate on criteria for case definition and vaccination strategies. This simple and safe technic constitutes a more and more reliable alternative to MRI and CT scan. A 53-year-old woman attended for a routine outpatient appointment for follow-up of antineutrophil cytoplasmic antibody-positive vasculitis. The proteins were overproduced in Escherichia coli, purified, biochemically characterised and used for crystallisation and structural analysis.

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The action of some detergents on the incorporation of glucose from uridine diphosphate glucose or adenosine diphosphate glucose into the potato tuber starch grain was studied. Keeping the plants in the dark for a prolonged period (24 hours) results in the disappearance of leaf starch from the control plants, but not from the plants with apoplastic invertase. Prostate movement during respiration was measured fluoroscopically using implanted gold fiducial markers. A large body of evidence supports the idea that accumulated genetic changes due to inherited as well as environmental factors underlie colorectal cancer development.

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The ipsilateral projection is more massive than the contralateral one. Overview of food- and water-borne zoonotic parasites at the farm level. Midterm outcome of mitral valve regurgitation after repair of atrioventricular septal defect.

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Slight decrease in respiratory rate and less severe histopathologic changes in the lungs were seen in corticosteroid-treated animals. The preparations of globulin and IgG obtained from hemostimulated mice, i.e. Tyrosine hydroxylase (TH), an iron-containing enzyme, catalyzes the first and rate-limiting step of catecholamine biosynthesis, and requires tetrahydrobiopterin (BH4) as a cofactor. The Tyr(16)-Leu(17) and Gly(20)-Glu(21) cleavage sites were hydrolyzed slightly more slowly, while the peptide bonds His(5)-Leu(6), His(10)-Leu(11), Glu(21)-Arg(22), Gly(23)-Phe(24) and Phe(24)-Phe(25) were more resistant to the enzyme attack.

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Review of diseases with the cellular system of inflammatory infiltrates More interestingly, high pretreatment levels of IgA rheumatoid factor are associated with a poor clinical response to TNFalpha inhibitors.

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The pathophysiological significance of reduced performance reserve of the pituitary-thyroid system Reproductive prognosis after abdominal metroplasty in bicornuate or septate uterus: a life table analysis. The cholesterol content was lowered in the lipoprotein fractions. It is interesting to compare the general pattern of the pressure reaction to the input flow with the force response to stretch which, according to the literature, can be observed in certain striated muscle preparations.

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Correlation analysis of preshift quantitative fit factors and corresponding workplace protection factors indicated no linear association between these two measures of performance. Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene. Since LC are potent antigen presenting cells, alterations in the expression of MHC Class II antigens on the surface of these cells will influence their ability to stimulate lymphocytes during the initiation of the cellular immune response to the accumulation of dental plaque. Serotonin topically applied caused cerebral arteriolar constriction.

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Increased levels of C-reactive protein (CRP) are associated with the presence and severity of atherosclerosis, and with increased risk of coronary events as well as of cardiac events after coronary percutaneous intervention. Modification of the hemodynamics of the perfused placenta by pharmacological agents Further analysis of the binding interface of cpSRP by mutagenesis studies and a pepscan approach demonstrates that the C-terminal alpha-helix of CD2 facilitates binding to cpSRP54. Optical vibrocardiography: a novel tool for the optical monitoring of cardiac activity.

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The designs were similar in that they featured random assignment of clusters to one of two treatment conditions and included a single intervening variable and outcome, but they differed in whether the mediator was measured at the participant or site level. innocua, the two species were different within the V9 region at nucleotides 1259 and 1292, in agreement with previous studies (R.-F.

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This can be attributed to the interconnected macropores within the graphene networks and nanopores on graphene sheets. Investigating primary human foreskin KC and HaCaT cells, we show here by semiquantitative RT-PCR and flow cytometric analysis that both translate IL-15 and IL-15R mRNA and express IL-15 and IL-15Ralpha protein on the cell surface, suggesting that human KC can employ IL-15 for juxtacrine signaling. Dipyridamole and benzydamine hydrochloride (anti-inflammatory drug) were separated on the ODS column and detected by the present system.

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A proposed new mechanism of traumatic aortic rupture: the osseous pinch. A high incidence of postoperative complication, revision, and mortality with poor quality of life confirm the serious prognosis of these individuals. In this study we assessed the skeletal muscle biopsy metabolome of healthy young, healthy older and frail older subjects to determine the effect of age and frailty on the metabolic signature of skeletal muscle tissue. The effects of a commercially available warm-up program on landing mechanics in female youth soccer players.

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Five of the cattle had reactions that were not identifiable relative to the reactions in rabbits. Moderate weight loss results in a significant decrease in leptin but no changes in adiponectin. The corresponding genes (ura-4, ura-1, ura-3) are not linked to each other or to ura-2, the gene for carbamoyl phosphate synthetase and aspartic transcarbamylase.

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Sensitive dependence of the coefficient of variation of interspike intervals on the lower boundary of membrane potential for the leaky integrate-and-fire neuron model. A description of the construction and of the apparatus is presented, and the experimental results used to establish the control parameters for Chlamydomonas reinhardtii colonies are discussed. Mathematical modeling is a key process in Systems Biology and the use of computational tools such as Cytoscape for omics data processing, need to be integrated in the modeling activity.

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The R line possesses high frequency haplotypes A7E5 and A9E1 with very low frequencies of the recombinants. Treating cultures of the microalgae Spirulina platensis or Monodus subterraneus with this herbicide brought about a reduction in the level of gamma-linolenic acid and in an increase in the level of linoleic acid. Effect of Neutron Irradiation on Properties of Pb(Mg(1/3)Nb(2/3))O3-PbTiO3. Neurocritically ill patients sometimes require repeat tracheostomy, which is traditionally considered a relative contraindication for percutaneous procedure.

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Intracoronary Transplantation of Mesenchymal Stem Cells with Overexpressed Integrin-Linked Kinase Improves Cardiac Function in Porcine Myocardial Infarction. We have also observed the morphological differentiation and inhibition of proliferation of two other transformed cell lines. HLA associations with a mixed CGN variant defining its genetic isolation were established. Selection of appropriate patients and procedures is vital and careful preparation of children and families minimizes fear and anxiety and streamlines the organizational aspects of care. Acute Ozone-Induced Pulmonary and Systemic Metabolic Effects Are Diminished in Adrenalectomized Rats.

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Effect of perfluorotributylamine-enriched alginate on nucleus pulposus cell: Implications for intervertebral disc regeneration. Semiquantitative reverse transcription-polymerase chain reaction was performed to measure RBD and Toll-like receptor (TLR) mRNA levels. The associated induction of tumor growth stasis is putatively interpreted as a pHe increase.

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An overactive Tibialis Posterior muscle seemed mainly responsible for the varus deformity. jejuni from the pool and from waterfowl in and around that pool were discussed, with special reference to method of recovery and sporadic distribution of other pathogenic microorganisms among migratory waterfowl.

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The null hypothesis of our study is that the incidence of vitamin K deficiency in mother-infant pairs exposed to anticonvulsant drugs is not higher than in controls. Current pH measurements do not take into account the effect of CO2. On the basis of these results, we discuss the possible phosphorelay networks in an Arabidopsis two-component system. Identification and characterization of novel porcine molecules specifically regulated on endothelial cells by human complement activation. Connectivity and degree of polymerization (DP) determine PAC bioavailability and bioactivity.

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The first stage of processing of binocular information in the visual cortex is performed by mechanisms that are bandpass-tuned for spatial frequency and orientation. It was hypothesized that cognitive performance would improve as blood lead level declined over time. These resultant IPF values often exceed unity, suggesting that the ingestion path is often the critical or limiting pathway for off-site CEDE to an individual. The data provide new information useful in understanding dielectric heating behavior and evaluating dielectric properties of such agricultural products for quality sensing applications.

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Wavelet-based estimation of hemodynamic response function from fMRI data. In the present study the connection of the subcommissural part of the globus pallidus and dorsal parts of the extended amygdala with the peripeduncular nucleus was investigated anatomically, using cholera toxin subunit B as a retrograde tracer, and functionally, using intracerebral injections of GABAergic compounds. An increase of solubility was observed only with the 1:3 drug/polymer microspheres and the comparison of the dissolution profiles of microspheres with pure griseofulvin resulted in an enhancing effect. After further treatment by reduction and carboxymethylation a carbohydrate-containing fragment of molecular weight 11990 was obtained (fragment BCd).

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O-glycosylation of serum IgA1 antibodies against mucosal and systemic antigens in IgA nephropathy. Effect of Plant Growth Regulators on Calcium-stimulated Serine Transport into Tobacco Cells. A number of recent studies suggest a link between in utero exposure to valproate (VPA) and low IQ and behavioural disorders in children of mothers with epilepsy.

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Effect of NOS inhibition on rat gastric matrix metalloproteinase production during endotoxemia. The p21 transfection of human glioma cells results in growth inhibition and G0/G1 arrest. Oral metoclopramide did not improve the absorption of amoxycillin.

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These studies provide evidence of the reliability and validity of single-item measures of symptom severity, psychosocial functioning, and quality of life. The SCN9A gene product is a critical component in human pain perception. Low disease activity state in rheumatoid arthritis: concepts and derivation of minimal disease activity.

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Using patch clamp techniques, single channel currents activated by ACh and anatoxin were recorded from frog interosseal muscle fibers under cell-attached condition and outside-out patches excised from cultured rat hippocampal neurons. It may occur as primary form (mostly hereditary) or secondary form, associated with various diseases, especially neoplastic or infectious diseases.

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Acropars demonstrated significant increases in marginal gap size. Pigs Can Be Used as a Large Animal Model for Autologous Fat Grafting.

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Here, we investigated whether HER2-positive breast cancers responded to sequential neoadjuvant anthracycline followed by paclitaxel plus carboplatin regimen in the absence of trastuzumab. And a potential major advantage of the IA technique is the ability to evaluate lesions that are characterized by increased blood flow. In higher eukaryotes, the regulation of pre-mRNA processing is still poorly known. Spiral CT of the lung in children with malignant extra-thoracic tumors: distribution of benign vs malignant pulmonary nodules. Chromatographic studies of cold agglutinins from tuberculous rabbits.

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Retraction: The structure of complement C3b provides insights into complement activation and regulation. A study of the tissue distribution of the cloned Sm GST 26 by immunoelectron microscopy shows similarities to Sm GST 28 in that they are present in the tegument and in subtegumentary parenchymal cells. The mixed population of mutagenic primers was generated by incorporating a mixture of A, G, C and T at specific sites during oligonucleotide synthesis. The effect of retinol on the changes of lipid composition in serum of rabbit. 48 acute paranoic schizophrenics were treated by high or low dosages of haloperidol and rated for improvement after 3 weeks of treatment.

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An experimental investigation of the nerve supply of the adrenal medulla of the cat. The authors believe that localized dilatation of the rectosigmoid should always be considered whenever a child is having intractable constipation after repair of an anorectal malformation and that sigmoid resection may be considered as a therapeutic alternative. Results of ternelin dosage for infant reoperations for persistent or recurrent secondary hyperparathyroidism in hemodialysis patients. During germination the chestnut (Castanea sativa L.) var ecotype 33 accumulates a large amount of asparagine in the cotyledons. De novo balanced complex chromosome rearrangement (CCR) involving chromosome 8, 11 and 16 in a boy with mild developmental delay and psychotic disorder.

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In addition, apoptosis was observed in HepG2 cells upon treatment with 5-FU alone and with the combination treatment, and in PLC/PRF/5 cells after single treatment with the IFN-alpha subtypes and after the combination treatment. We report on successful percutaneous endovascular stent-graft treatment of an acute type B dissection accompanied by an intramural haematoma in the ascending aorta as primary and sole form of treatment. Etiologies were determined on the basis of clinical examination, related fluconazole normon 150 mg precious memories blood investigations and radio-imaging findings. Sera were assayed for the presence of antisurfactant antibodies by enzyme-linked immunosorbent assay (ELISA).

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To investigate mutation of APC gene in sporadic colorectal tumors. Decomposition of the previously generated alkyltrimethylammonium salts followed by unspecific cracking of the resulting nitrogenated compounds happened at higher temperatures. In contrast, Dex treatment inhibited the IL-1beta-induced production of GM-CSF, IL-6, IL-8, MCP-3, and RANTES, but not MCP-1. These findings support the hypothesis that in order to survive a critical illness, patients must achieve a lofibra tablets for children high level of VO2.

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