Epivir is a pyrimidine analog reverse transcriptase enzyme inhibitor active against human immunodeficiency virus type I (HIV1), HIV2, Hepatitis B virus, in vitro and in vivo. Intracellularly it is metabolized to its active triphosphate form by multiple kinases. The triphosphate form competes with deoxycytidine triphosphate for binding to reverse transcriptase, and the incorporation of this 3TC-triphosphate (3TC-TP) form in viral DNA results in chain termination. It is FDA approved for treatment of HIV infections in children and adults in a three drug regimen along with other nucleoside analogs, protease inhibitors and non-nucleoside reverse transcriptase inhibitors.
Other names for this medication:
Lamivudine,
Epivir,
Heptovir,
Lamivudina,
Lamzid,
Zeffix,
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